"
\n<h2 id=\"em-tissue-coupling-tutorial\">Electro-mechanical coupling at the\ \ tissue scale\n

This tutorial elucidates the setting up of electro-mechanically\ \ coupled tisue simulations. As an example we use a simpliefied model of a left\ \ ventricular wedge preparation. For the sake of computational efficiency the apico-basal\ \ and circumferential dimension of the wedge are chosen by default to be small and\ \ the resolution of the model is coarse. As in the matching single cell stretcher\ \ experiment the same EP models (TT2, GPB) and stress models (TanhStress, LandStress,\ \ GPB-LandStress-model) are available which cover all three coupling modes (activation-time\ \ based ECC, weak calcium-driven ECC and strong calcium-driven ECC). The differences\ \ between coupling modes are illustrated in <code class=\"interpreted-text\" role=\"\ numref\">fig-ECC-physiology.

\n<h2 id=\"experimental-setup\">Experimental\ \ setup\n
\n<img src=\"04_em_coupling/ECC_wedge_experiment.png\" id=\"\ fig-ECC-wedge\" class=\"align-center\" style=\"width:40.0%\" alt=\"\" />
The\ \ setup uses a simple LV wedge preparation where the apicobasal and circumferential\ \ dimension can be chosen by setting the --length and --width\ \ input parameters. The wedge is mechanically fixated through homogeneous Dirichlet\ \ boundary conditions at the apical face of the wedge. At the anterior and posterior\ \ faces homogeneous Dirichlet boundary conditions are also applied, preventing any\ \ displacement in radial (z-axis) and circumferential (x-axis) direction, but allowing\ \ the wedge to slide along the apico-basal (y-axis) direction. Fiber rotation is\ \ set to standard values with -60 degrees at the epicardiacl face and +60 degrees\ \ at the endocardial face. The wedge is electrically stimulated epicardially at\ \ the center of the preparation.
\n
\n<h2 id=\"input-parameters\"\

Input parameters\n

To run the examples of this tutorial do

\n<div class=\"\ sourceCode\" id=\"cb1\"><pre class=\"sourceCode bash\"><code class=\"sourceCode\ \ bash\"><span id=\"cb1-1\"><a href=\"#cb1-1\" aria-hidden=\"true\"><span class=\"\ bu\">cd <span class=\"va\">${TUTORIALS}/04_EM<span class=\"op\">>_tissue/04_EM_coupling\n\

To inquire the exposed experimental input parameters run

03_unloading 05_MEF